content provided by Healthwise
Chronic myelogenous leukemia (CML)
Chronic myelogenous leukemia (CML) is a type of cancer that causes the body to produce large numbers of immature and mature white blood cells (myelocytes). It is sometimes referred to as chronic myeloid leukemia or chronic granulocytic leukemia.
CML is more common in men than in women. It occurs more frequently in adults in their 50s and is rarely seen in children.
Symptoms of CML include weakness and fatigue, fever, night sweats, poor appetite, and weight loss. The spleen may become swollen and painful.
CML is classified into three distinct phases.
- Chronic phase: In this phase, the bone marrow fills with large numbers of abnormal white blood cells (myeloproliferation) in various stages of maturation. Symptoms may not be present. Most cases of CML are diagnosed during the chronic phase.
- Accelerated phase: In this phase, the bone marrow loses its ability to function because abnormal white blood cells crowd out other functioning cells. In this phase, treatment may not be as effective.
- Blast crisis phase: In this phase, CML suddenly transforms into another, more severe form of leukemia.
Treatment for CML depends on the stage of the disease and may include chemotherapy, radiation, or bone marrow transplant.
Credits
| Author | Jeannette Curtis |
| Author | Caroline Rea, RN, BS, MS |
| Editor | Kathleen M. Ariss, MS |
| Editor | Susan Van Houten, RN, BSN, MBA |
| Associate Editor | Tracy Landauer |
| Associate Editor | Pat Truman |
| Primary Medical Reviewer | Patrice Burgess, MD - Family Medicine |
| Primary Medical Reviewer | Adam Husney, MD - Family Medicine |
| Primary Medical Reviewer | Kathleen Romito, MD - Family Medicine |
| Last Updated | May 25, 2007 |
| Last updated: | May 25, 2007 |
|---|---|
| Author: | Caroline Rea, RN, BS, MS |
| Reviewed By: | Kathleen Romito, MD - Family Medicine |
| Editors: | Susan Van Houten, RN, BSN, MBA, Pat Truman |
© 1995-2007, Healthwise, Incorporated. Healthwise, Healthwise for every health decision, and the Healthwise logo are trademarks of Healthwise, Incorporated.
This information is not intended to replace the advice of a doctor. By using AOL Body, you indicate that you have read, understood, and agreed to our Terms of Service, and AOL Body Advertising Policy. Read more about our content partners.
