Factor XIII Deficiency

Important

It is possible that the main title of the report Factor XIII Deficiency is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.

Synonyms

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• Fibrin Stabilizing Factor Deficiency
• Fibrinase Deficiency
• Fibrinoligase Deficiency
• Laki-Lorand Factor Deficiency
• Plasma Transglutaminase Deficiency

Disorder Subdivisions

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• Congenital Factor XIII Deficiency
• Acquired Factor XIII Deficiency

General Discussion

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Factor XIII Deficiency is an extremely rare inherited blood disorder characterized by abnormal blood clotting that may result in abnormal bleeding. Associated symptoms and findings occur as the result of a deficiency in the blood clotting factor F13A1 (Factor XIII). In affected individuals, the blood fails to clot appropriately, resulting in poor wound healing. Blood may seep into surrounding soft tissues, resulting in local pain and swelling. Internal bleeding may occur; approximately 25 percent of affected individuals experience bleeding in the brain (intracranial hemorrhage). Factor XIII Deficiency may be inherited as an autosomal dominant genetic trait. The disease may also be acquired in association with other disorders such as Sickle Cell Disease or Henoch-Schonlein Purpura.

Resources

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National Hemophilia Foundation

116 West 32nd Street

11th Floor

New York, NY 10001

USA

Tel: 2123283737

Fax: 2123283795

Tel: 8004242634

Email: gwidlundDhemophilia.org

Internet: http://www.hemophilia.org



NIH/National Heart, Lung and Blood Institute

31 Center Drive MSC 2480

Building 31A Rm 4A16

Bethesda, MD 20892-2480

Tel: (301)592-8573

Fax: (240)629-3246

Email: nhlbiinfo@rover.nhlbi.nih.gov

Internet: http://www.nhlbi.nih.gov/



World Federation of Hemophilia

1425 Rene Levesque Boulevard West

Suite 1010

Montreal

Quebec, Intl H3G 1T7

Canada

Tel: 514-875-7944

Fax: 514-875-8916

Email: wfh@wfh.org

Internet: http://www.wfh.org

For a Complete Report

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This is an abstract of a report from the National Organization for Rare Disorders, Inc. ® (NORD). A copy of the complete report can be obtained for a small fee by visiting the NORD website. The complete report contains additional information including symptoms, causes, affected population, related disorders, standard and investigational treatments (if available), and references from medical literature. For a full-text version of this topic, see http://www.rarediseases.org/search/rdblist.html

The information provided in this report is not intended for diagnostic purposes. It is provided for informational purposes only. NORD recommends that affected individuals seek the advice or counsel of their own personal physicians.

It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report.

This disease entry is based upon medical information available through the date at the end of the topic. Since NORD's resources are limited, it is not possible to keep every entry in the Rare Disease Database completely current and accurate. Please check with the agencies listed in the Resources section for the most current information about this disorder.

For additional information and assistance about rare disorders, please contact the National Organization for Rare Disorders at P.O. Box 1968, Danbury, CT 06813-1968; phone (203) 744-0100; web site www.rarediseases.org or email orphan@rarediseases.org

Last Updated:   8/7/2007

Copyright   1989, 1991, 1993, 1997, 1999, 2007 National Organization for Rare Disorders, Inc.