Mitoxantrone

Mitoxantrone
Examples
How It Works
Why It Is Used
How Well It Works
Side Effects
What To Think About
Credits

Content provided by Healthwise

Examples

Brand Name	Chemical Name
Novantrone	mitoxantrone

Mitoxantrone is given as an intravenous (IV) injection.

How It Works

Mitoxantrone belongs to a group of medications that interfere with the growth of the cancer cells (antineoplastics). It is used to treat some kinds of cancer.

Why It Is Used

Mitoxantrone is used to treat acute myelogenous leukemia (AML) and non-Hodgkin's lymphoma (NHL). It may also be used to treat other kinds of cancer. Mitoxantrone is also used to treat multiple sclerosis.

How Well It Works

Mitoxantrone is an effective treatment for non-Hodgkin's lymphoma and acute myelogenous leukemia. It also reduces the frequency of relapses of multiple sclerosis.

Side Effects

Side effects of mitoxantrone are common and can include:

Nausea or vomiting.
Hair loss.
Damage to the muscle of the heart. This can be serious.
Increased risk of infections, especially urinary tract infections.
Changes in a woman's menstrual cycle.
Mouth sores (stomatitis).
Diarrhea or constipation.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

Mitoxantrone should be administered only under the supervision of a medical oncologist, hematologist, or neurologist.

Mitoxantrone may cause serious, even fatal, heart damage in some people. Frequent tests are needed to monitor heart function while taking this medication.

Mitoxantrone can affect your ability to have children. You may not be able to become pregnant or father a child after taking mitoxantrone. Discuss fertility with your doctor before starting treatment with this drug.

Mitoxantrone can cause birth defects. Do not use this medication if you are pregnant or wish to become pregnant or father a child while you are taking it.

Women who take this medication may experience menopausal symptoms, including hot flashes and vaginal dryness.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

Credits

Author	Kathe Gallagher, MSW
Editor	Alison Allen
Editor	Kathleen M. Ariss, MS
Associate Editor	Pat Truman
Primary Medical Reviewer	Caroline S. Rhoads, MD - Internal Medicine
Specialist Medical Reviewer	Joseph O'Donnell, MD - Hematology
Last Updated	November 30, 2006

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Last updated:	November 30, 2006
Author:	Kathe Gallagher, MSW
Reviewed By:	Caroline S. Rhoads, MD - Internal Medicine, Joseph O'Donnell, MD - Hematology
Editors:	Kathleen M. Ariss, MS, Pat Truman

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