RSV-IGIV to prevent RSV infection

Examples

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Brand Name	Chemical Name
RespiGam	respiratory syncytial virus immune globulin intravenous (RSV-IGIV)

How It Works

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RSV-IGIV is used to help prevent or reduce complications of respiratory syncytial virus (RSV) infection, such as pneumonia and bronchiolitis. RSV-IGIV is made up of several proteins (antibodies) obtained from many human blood donors. The antibodies were created by the donors' natural defense (immune) systems to fight RSV.

RSV-IGIV is given through a vein (intravenous, or IV) in monthly doses for the entire RSV season (usually from November through March). It is given over about 4 hours in a hospital or doctor's office or at home.

Why It Is Used

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RSV-IGIV is given only to help prevent RSV in children who have a high risk of developing complications, such as those with chronic lung disease or heart problems. If your baby was born early or has health problems, talk to your doctor about the need to prevent RSV.

Palivizumab, another type of monoclonal antibody used to prevent RSV, is generally preferred over RSV-IGIV. However, either medicine can be given for children at risk for RSV complications.

This medicine is not an effective treatment for children already infected with RSV. This medicine should also not be given to children who have a cyanotic congenital heart defect.

How Well It Works

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RSV-IGIV provides moderate protection for babies.¹ Children with chronic lung disease or heart disease were shown to have fewer hospital stays and fewer stays in intensive care when they were given preventive treatment with RSV-IGIV or palivizumab (monoclonal antibody).² (Palivizumab is another type of antibody used to prevent RSV in high-risk babies.)

Side Effects

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Side effects of RSV-IGIV are uncommon but can include:

• Allergic reaction.
• Fever.
• Nausea and vomiting.
• Pulmonary edema.

Although there is a potential for contracting HIV infection, hepatitis, or other diseases from the blood product that makes up RSV-IGIV, the risk is extremely rare. All blood donors are carefully screened and blood products are treated for viruses. This process has virtually completely eliminated any risk of exposure from RSV-IGIV.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

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Immunizations with measles-mumps-rubella (MMR) and chickenpox vaccines should not be given for 9 months after the last dose of RSV-IGIV. The medicine prevents the child from developing antibodies to these vaccines. Other immunizations should be given as scheduled according to the childhood immunization schedule . Children who receive RSV-IGIV do not need an extra dose of any vaccine beyond the normal recommendations. ³

Palivizumab, another type of antibody used to prevent RSV in high-risk babies, may be preferred over RSV-IGIV. A child taking palivizumab can be immunized against other diseases without waiting.

Preventive treatment with RSV-IGIV should continue throughout the RSV season, regardless of whether a child gets RSV. Different strains of RSV can circulate within a community during the same year, so treatment with RSV-IGIV may still offer protection from infection.

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

References

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Citations

1. Hall CB (2001). Respiratory syncytial virus and parainfluenza virus. New England Journal of Medicine, 344(25): 1917–1928.

2. Lozano JM (2005). Bronchiolitis. Clinical Evidence (14): 1–15.

3. American Academy of Pediatrics (2003). Revised indications for the use of palivizumab and respiratory syncytial virus immune globulin intravenous for the prevention of respiratory syncytial virus infection. Pediatrics, 112(6): 1447–1452. Also available online: http://aappolicy.aappublications.org/cgi/reprint/pediatrics;112/6/1447.pdf.

Credits

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Author	Amy Fackler, MA
Author	Debby Golonka, MPH
Editor	Susan Van Houten, RN, BSN, MBA
Associate Editor	Pat Truman
Primary Medical Reviewer	Kathleen Romito, MD - Family Medicine
Primary Medical Reviewer	Michael J. Sexton, MD - Pediatrics
Specialist Medical Reviewer	W. David Colby, MSc, MD, FRCPC - Infectious Disease
Last Updated	August 9, 2006