Spironolactone for PMS

Examples

---

Brand Name	Chemical Name
Aldactone	spironolactone

Spironolactone is taken orally during the time when premenstrual syndrome (PMS) symptoms occur.

How It Works

---

Taken only during the premenstrual phase, spironolactone blocks the body's use of the hormone aldosterone, which causes fluid retention in the body. This has a diuretic effect, eliminating excess salt and water in the body.¹

Why It Is Used

---

Spironolactone is sometimes used when bloating, water retention, and weight gain are the main symptoms of PMS.

How Well It Works

---

Spironolactone effectively reduces premenstrual bloating, breast tenderness, and weight gain.¹

Side Effects

---

Side effects of spironolactone use are uncommon but may include:

• Cramping, diarrhea.
• Drowsiness, lack of energy.
• Headache, confusion.
• Irregular menstrual periods.

Side effects go away when use of spironolactone is stopped.

See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)

What To Think About

---

Before considering spironolactone treatment, see whether reducing the amount of salt and caffeine in your diet relieves premenstrual bloating, water retention, or weight gain.

Do not take potassium supplements when using spironolactone—doing so may result in excessive potassium levels, which can cause lethal heartbeat problems (arrhythmias).

Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.

References

---

Citations

1. Dickerson LM, et al. (2003). Premenstrual syndrome. American Family Physician, 76(8): 1743–1752.

Credits

---

Author	Kathe Gallagher, MSW
Editor	Kathleen M. Ariss, MS
Associate Editor	Pat Truman
Primary Medical Reviewer	Renée M. Crichlow, MD - Family Medicine
Primary Medical Reviewer	Kathleen Romito, MD - Family Medicine
Specialist Medical Reviewer	Deborah A. Penava, BA, MD, FRCSC, MPH - Obstetrics and Gynecology
Last Updated	July 7, 2006